Independent associations of TOMM40 and APOE variants with body mass index.

Mega‐analysis of the effects of each APOE genotype compared with the ε3ε3 genotype showed highly significant associations for the ε3ε4 ( β = −1.41, p = 7.68 × 10 −8 ) and ε4ε4 ( β = −2.41, p = 3.32 × 10 −3 ) genotypes and suggestive‐effect significance for the ε2ε3 genotype ( β = 0.55, p = 8.26 × 10 −2 ) (Table 1 , Model 1). 2.3 Independent associations of TOMM40 and APOE polymorphisms with BMI Despite moderate LD between rs2075650 and rs429358 (Figure 1 ), bivariate mega‐analysis with these SNPs identified their independent associations with BMI, although their effects became smaller (Table 1 , Model 2).

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The rs7412 minor allele, coding the APOE ε2 allele, showed the opposite‐direction nominally significant effect in mega‐analysis ( β = 0.58, p = 3.04 × 10 −2 ).

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There was an apparent trend for an increasing magnitude of the effect size for the older heterozygous carriers of rs429358 until the age of about 80 years, independent of rs2075650, rs157580, and rs7412.

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