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Plasma Calcitonin Gene-Related Peptide: A Potential Biomarker for Diagnosis and Therapeutic Responses in Pediatric Migraine.

Front Neurol · 2019 · PMC6353836 · PMID 30733702

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showed a trendno p-value reported
Topiramate also showed a trend toward improving headaches in several open-label or randomized, double-blind, placebo-controlled studies in children with migraine ( 48 , 49 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.