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The <i>TYK2</i>-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

Front Immunol · 2019 · PMC6355696 · PMID 30740104

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Under all conditions, Tyk2 P / P B cells exhibited a trend for diminished IL-6 production compared to control Tyk2 NP / NP or heterozygous (Tyk2 NP / P ) B cells (Figure 2D) but these differences did not reach statistical significance.

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