Targeted deletion of fibrillin-1 in the mouse eye results in ectopia lentis and other ocular phenotypes associated with Marfan syndrome.

In both genotypes, there was a modest decline in IOP from ≈18 mm/Hg in young animals to ≈12 mm/Hg in aged animals, but pressure differences between control and mutant eyes did not reach statistical significance ( Fig. 9 C).

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