Clostridium ramosum regulates enterochromaffin cell development and serotonin release.

Although 5-HT levels were elevated after stimulation with bacterial supernatants the observed differences did not reach statistical significance (for ECs: supernatants versus vehicle: 0.17 ± 0.06 μM versus 0.05 ± 0.01 μM, for SI organoids: supernatants versus vehicle: 5.81 ± 1.07 nM versus 0.60 ± 0.39 nM; for colonic organoids: 5.28 ± 0.79 nM versus 0.45 ± 0.46 nM).

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