Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.

2 b ) reveals that it is similarly expressed at baseline in the nine cell types studied, but the magnitude of the response ranges from strong and highly significant up-regulation in neutrophils to the absence of any detectable change in any of the nonhematopoietic cells studied.

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The genes CD19 and SYK had lower mean expression values after glucocorticoid treatment in vivo, but the difference did not reach statistical significance, whereas the gene that encodes the key upstream kinase LYN was significantly reduced in expression after glucocorticoid administration in vivo, although it had not reached statistical significance in vitro.

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