However, several of these proteins were similar in effect size, and therefore, the reduced sample size in the cognitively unimpaired meant that they did not reach statistical significance [e.g., prothrombin (F2); Fig. 1 ].
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A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.
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We found a highly significant association between NfL and Aβ burden, in keeping with previous studies, although we do not find an age-related increase of plasma NfL ( 23 ).