Among flavonoids from A group, which carry substitutions at the 3-position of C-ring and at 3′- and 4′-positions of B-ring, a clear trend is observed: from flavonoids A1 to A5 , the –OH groups at 3-position of C-ring and at 3′-position of B-ring establish hydrogen bonds with Asp300, while the –OH group at 4′-position of B-ring establishes hydrogen bonds with Asp197, with this hydrogen bonding network being optimized in flavonoid A5 .
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Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure-activity relationship.
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