Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery.

J Exp Clin Cancer Res · 2019 · PMC6367822 · PMID 30736829

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Similarly, treatment with N-EV showed a trend in increasing apoptosis of A549 and H23 cells, while H-EV treatment significantly reduced A549 and H23 cell apoptosis in in vitro culture.

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