By using cell cycle markers for total cell cycle activity (Ki-67), we found a clear trend towards reduced cell proliferation and significantly lower cell cycle activity (CcnD1) in NEMO Δhepa /Fas lpr livers compared with NEMO Δhepa (Fig. 2c, d ; Supplementary Figure 2d ).
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Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease.
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