showed a trendp = 0.104
Four out of ninety-nine lncRNAs, namely NRIR, PSMB8-AS1, RP5-1091N2.9, and RP11-24F11.2, were expressed at significantly higher levels in at least two groups of SSc patients as compared to their respective healthy donors in the “definite SSc” cohort ( Figure 3A ), whereas only NRIR was significantly up-regulated in ncSSc and showed a trend in eaSSc (FC = 1.30, p = 0.104) in the “non-fibrotic” cohort ( Figure 3B ).