CXCL17-derived CD11b⁺Gr-1⁺ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB.

There were increased trends in the expressions of PDGF-AA, VEGF-A, and EGF basic, although they did not reach statistical significance (Fig. 4 c–f). rmCXCL17 increased the expression of PDGF-BB in CD11b + Gr-1 + MDSCs isolated from lungs of normal mice in situ (Fig. 4 g).

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