When we calculated the percentage of “off-responding” neurons in comparison with the overall number of responding cells within the same fields of view, we observed a significant increased proportion of “off-responders” specifically in APP/PSEN1 mice (16.57 ± 4.68%, Kruskal–Wallis test, P = 0.0068, Fig 2C ), which tended to be exacerbated in aged as compared with adult transgenic APP/PSEN1 animals (even though the difference between “adult” and “aged” APP/PSEN1 did not reach statistical significance, Fig S3 ).
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