Examination of protein extracts from the hearts of mixed background mice after TAC revealed a trend towards increased expression of many ER stress-activated proteins and chaperones such as binding immunoglobulin protein (BiP), calreticulin, hypoxia up-regulated protein 1 (Hyou1), arginine-rich, mutated in early-stage tumors (ARMET), protein disulfide isomerase (PDI), stromal cell derived factor 2 like 1 (Sdf2l1), as previously described by us 2 , and gene-deleted mice lacking Atf6 or Atf6b showed a trend towards reduced expression of some of these ER stress responsive proteins (Fig. 1e ).
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Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.
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