Mutation of the residues, which could be phosphorylated in the SDSDY sequence, showed a trend toward increased responses reaching statistical significance in response to CD3 mAb (shown for 0·25 μg/ml) when all three were mutated (Fig. 2 b, ADADF).
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A sequence conserved between CD5 and CD6 binds an FERM domain and exerts a restraint on T-cell activation.
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