Topiramate is more effective than acetazolamide at lowering intracranial pressure.

Subcutaneous administration of acetazolamide showed a trend towards a reduction in ICP at clinical (19% reduction) and high doses (20% reduction); however, it was not significantly different compared to the 2% and 4% NaCl controls respectively ( Figure 1(c) and ( d ), and Table 2 ).

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