Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.

The rate of glucose disappearance (Rd) trended higher in Bcl6 AKO mice but did not reach statistical significance ( Figure 2E ), while tissue-specific glucose uptake of 14 C-deoxyglucose tracer revealed increased accumulation in gastrocnemius and vastus lateralis muscles as well as PgAT but decreased uptake into brown adipose tissue (BAT) ( Figure 2F ).

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