Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.

Compared to male mice, female mice showed smaller infarct volume, lower neurological score, and less body weight loss independent of genotype, although these changes did not reach statistical significance (Additional file 1 : Figure S3). α5-PKO mice have reduced neuronal death after ischemia-reperfusion injury To investigate if loss of mural cell-derived laminin-α5 affects neuronal death after ischemic injury, we performed FJC staining, which labels degenerating neurons [ 11 , 72 ].

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