MiR-146a wild-type 3' sequence identity is dispensable for proper innate immune function in vivo.

Although we noticed a modest trend for increased production of IL-6 by LPS-challenged mir-146a 3′F/3′F BMDMs, this did not reach statistical significance ( Fig 5D ), and even this trend was significantly reduced when levels of IRAK1 protein were assessed ( Fig 5E and F ).

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