Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals.

In addition, we observed no changes in preference ( Table 2 ), perhaps due to the low level of concurrent water drinking across the 2-h session ( Dhaher et al., 2009 ; Seif et al., 2015 ; Hartog et al., 2016 ; Lei et al., 2016b ), although concurrent water intake was greater during 2bc-IA versus 2bc-DID sessions ( p = 0.0032 Mann–Whitney) and 2bc-IA preference change was nearly significant (not shown).

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