Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[3 H]3 methoxy phenyl)-N'-methylguanidine ([3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.

Pharmacol Res Perspect · 2019 · PMC6381215 · PMID 30784206

Europe PMC DOI

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0.1400

closest p · 2.8× alpha

0.1400

boldest claim

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did not reach statistical significanceP = 0.14not close (p > 0.1)

For [ 3 H]MK‐801, the agonists induced a 4‐fold decrease in mean K d values compared to baseline, which did not reach statistical significance by two‐way ANOVA ( P = 0.14; LSD post‐hoc tests).

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Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[<sup>3</sup> H]<sub>3</sub> methoxy phenyl)-N'-methylguanidine ([<sup>3</sup> H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.

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