DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

Gastroenterology · 2018 · PMC6381389 · PMID 29031501

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a clear trendno p-value reported

Despite the relatively small sample number, CD-associated DMPs (ie, identified in Figure 3 ) showed a clear trend to be also differentially methylated in CD-derived compared with control organoids.

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highly significantno p-value reported

We observed highly significant enrichment of DMRs, DEGs, and rDMRs in both colonic and ileal IECs for IBD risk loci, while limited enrichment was found for genetic variants that have been linked to other multifactorial diseases with an immune-mediated pathogenesis, such as Type 1 diabetes and multiple sclerosis ( Supplementary Figure 7 ).

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