Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.

Finally, the mean total charge transfer (a parameter that reflects both the amplitude and frequency of miniature synaptic events) for mIPSCs was significantly decreased in CYFIP1-overexpressing cells, while mEPSC charge transfer showed a trend toward an increase ( Figures 4 M and 4N).

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