Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.

In mice administered with gliadin at a low dose (12.5 mg/kg), the lesion index tended to be higher in mice with high dose of indomethacin (30 mg/kg) than mice with 10 and 20 mg/kg of indomethacin, but it did not reach statistical significance ( Fig 1F ).

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