Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

After 5 weeks of culture, the differences in lysates were no longer statistically significant, but there was a clear trend of increased neuronal MAP2 and decreased glial GFAP expression that supported our other results from 3-week cultures ( Fig 1H ).

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