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Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract.

Front Genet · 2019 · PMC6384416 · PMID 30828347

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Scoring the three network models with the datasets from IL13-treated lung cells highlighted the specificities of the different networks: IL13-induced airway mucus production affected several hubs in the hyperplasia/metaplasia model, notably the SPDEF transcription factor, while impacts on the cilium assembly and ciliary beating models did not reach statistical significance.

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