Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants.

PLoS Pathog · 2019 · PMC6386422 · PMID 30742691

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showed a trendno p-value reported

Interestingly, among the three or four mutation viruses, this virus elicited the highest levels of MCP-1, MCP-3 and IL-18 and showed a trend towards production of higher numbers of CD8 + T cells, possibly underlying its superior protective efficacy.

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