Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery-Construction of a Diversity-Optimized Halogen-Enriched Fragment Library.

Front Chem · 2019 · PMC6387937 · PMID 30834240

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a clear trendno p-value reported

Especially when looking at successful leads, derived from fragments, a clear trend toward larger deviation from planarity can be observed (Johnson et al., 2018 ).

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