While no differences in hippocampal CD68 had been seen with infusion of subpressive Ang II for 1 week, increasing Ang II perfusion to 2 weeks led to a significant rise in CD68 mRNA (mean increase 27%, p = 0.0090, Additional file 2 : Figure S1C, n = 7) and to a similar increase in GFAP mRNA (mean increase 29%), although this difference did not reach statistical significance ( p = 0.117, Additional file 2 : Figure S1D, n = 7).
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Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice.
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