Robust gene signatures of kidney aging and their correlation with functional and structural dimensions of kidney health Of 19 replicated genes, 14 showed at least 1 nominally significant association with 1 of 5 biochemical or histologic measures of renal functional and structural integrity known to deteriorate with age (i.e., estimated glomerular filtration rate, glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arterial/arteriolar narrowing) in up to 160 individuals from the TRANSLATE Study ( Supplementary Tables S10–S14 , Figure 2 , and Supplementary Figure S2 ).
← all excerpts
Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.
1
—
—