Acute Cannabinoids Produce Robust Anxiety-Like and Locomotor Effects in Mice, but Long-Term Consequences Are Age- and Sex-Dependent.

Front Behav Neurosci · 2019 · PMC6391357 · PMID 30842732

Europe PMC DOI

hedged sentences

0.0505

closest p · 1.0× alpha

0.0800

boldest claim

The sentences

a strong trendp = 0.0505so close (0.05 < p ≤ 0.1)

Elevated Plus Maze Activity In pair-housed males, a Drug ∗ Age ANOVA revealed a strong trend toward an interaction of drug treatment and age on time spent in the open arms of the EPM following acute cannabinoid pretreatment [ F (3,67) = 2.73, p = 0.0505].

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a weak trendp = 0.08so close (0.05 < p ≤ 0.1)

One-way ANOVAs for each age group indicated a weak trend of drug history in adult-treated animals [ F (3,33) = 2.46, p = 0.08], with a THC+CBD history significantly reducing object discrimination compared to a vehicle history [ t (33) = 2.56, p < 0.05, d = 1.51] ( Figure 6B ).

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