Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits.

3C ; Table 3 ), and a marginally nonsignificant Drug effect.

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Among female mice, neither the ISO nor the AIR groups displayed a significant preference for the novel versus the familiar mouse, although the AIR controls showed a trend toward spending more time in the investigation zone surrounding the novel conspecific compared to the zone times observed for the familiar mouse (Fig. 3G ; Table 3 ).

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Subsequent comparisons showed ISO mice remained on the rod for a significantly shorter duration compared to the AIR control group on day 3, according to the Bonferroni criterion (critical alpha p < 0.008), and large, yet marginally significant, differences were also observed for day 2.

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The male AIR group also showed a nonsignificant trend toward more entries into the zone surrounding the novel mouse compared to entries of the ISO males (Fig. 3H ; Table 3 ).

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