Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury.

However, consistent with our observations after a single injury, SOCS3 MscKO muscles contained a higher proportion of fibers with a single central nucleus after two sequential injuries ( Fig 4I ; ** P < 0.01) compared to muscles from control mice which showed a trend towards a higher proportion of fibers with more than two centralised nuclei ( Fig 4I ; P = 0.12).

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