Effects of genetic variants on serum parathyroid hormone in hyperparathyroidism and end-stage renal disease patients: A systematic review and meta-analysis.

In subgroup analysis by ethnicity for VDR rs1544410 gene polymorphism, we found significant differences under dominant model ( SMD : −0.18 [−0.32, −0.05], P < .01) and AA versus GG comparison ( SMD : −0.29 [−0.52, −0.06], P < .01) in Asian patients with ESRD, while nominally significant results ( P < .05) were observed for AG versus GG and AA versus GG comparisons in European individuals with ESRD.

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Marginally significant differences ( P < .05) among European individuals were observed for AG versus GG ( SMD : −0.30 [−0.03, −0.57], P < .03) and AA versus AG comparisons ( SMD : −0.28 [−0.55, −0.01], P < .04).

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