Time to Include Fine Specificity Anti-Citrullinated Protein Antibodies in the Routine Diagnosis and Management of Rheumatoid Arthritis?

Arthritis Rheumatol · 2019 · PMC6393168 · PMID 30378761

Europe PMC DOI

hedged sentence

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

approaching significanceP = 0.073so close (0.05 < p ≤ 0.1)

However, when both fine specificities were combined with anti‐CCP2, the 28‐joint Disease Activity Score (DAS28) 5 in patients positive for all 3 markers was significantly increased ( P = 0.038) compared to that in patients positive for only CCP2, with the difference in the Health Assessment Questionnaire score 6 approaching significance ( P = 0.073).

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