Leakage incidents were restricted and infrequent (1–6 incidents per cortical section in average), but more importantly the trend of leakage incidence being larger in diabetic Lepr db/db mice compared to control normoglycaemic littermates did not reach statistical significance (Figs 1c and S1 ).
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Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction.
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