Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy.

Mol Ther Nucleic Acids · 2019 · PMC6393707 · PMID 30825671

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did not reach statistical significanceno p-value reported

Although differences in therapeutic efficacy between mice treated with AAV/miR(5,B,7)-PEDF-PE and the group receiving AAV/miR(5,B,7)-AsR-PE did not reach statistical significance, the dual-acting vector showed efficacy despite being affected in functional titers leading to lower expression of EGFP in the RPE cells, as described above.

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