From pooled analysis of two early randomized trials’ results (French FFCD trial and English ENG trial), adjuvant fluorouracil potentially improved OS (median 62.2 mo vs 47.3 mo, P = 0.095) and PFS (median 27.9 mo vs 18.8 mo, P = 0.058) compared with surgery alone, but both did not reach statistical significance[ 130 ].
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