Moreover, mice treated with MEM also showed a trend of CRS-induced abnormality reversal in the number of open- and closed-arm entries and in closed-arm residence time.
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Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
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On day 27, mice treated with 5 or 10 mg/kg MEM also showed a nonsignificant trend of CRS-induced behavioral abnormality reversal compared to CRS-only mice, indicating a beneficial effect of MEM on EPM test performance in mice subjected to CRS ( Figure 1(d) ). 3.2.
We found that MEM treatment caused an increasing trend of the AT8-reactive P-tau level in the frontal cortex of mice without CRS but without statistical significance (Figures 5(d) and 5(e) ).