Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease.

J Neuroinflammation · 2019 · PMC6393982 · PMID 30813952

Europe PMC DOI

hedged sentences

0.0210

closest p · 0.4× alpha

0.0500

boldest claim

The sentences

nominally significantp = 0.021actually significant

Results We observed a nominally significant association of the IL1β rs1143623 C allele with the risk for Parkinson’s disease ( OR = 0.59; 95%CI = 0.38–0.92, p = 0.021).

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a nonsignificant trendp = 0.050actually significant

The IL1β rs1143623 T allele showed a nonsignificant trend towards association with lower odds for developing OH (OR = 0.57; 95%CI = 0.32–1.00, p = 0.050), while heterozygotes had nominally significant lower odds for developing OH (OR = 0.51; 95%CI = 0.28–0.93, p = 0.028).

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