The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension.

Although not significant, the association of MBG and decline in GFR still showed a trend for significance after adjustment for baseline variables mean plasma calcium (β = -.375; p = .053), systolic BP (β = -.361; p = .056) and albuminuria (β = -.372; p = .063), but not for present diabetes mellitus type I or II at baseline (N = 6; β = -.339; p = .074), history of smoking at baseline (β = -.319; p = .107), and fasting glucose at baseline (β = -.301; p = .106), LDL at baseline (β = -.363; p = .081), bicarbonate (β = -.165; p = .442), and 24-hour sodium excretion (β = -.375; p = .077).

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