Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.

These findings are unique and highly significant in that they describe a previously unidentified, tightly regulated signaling pathway propelled by Nox1 in control of Gremlin1 that promotes pulmonary endothelial cell proliferation and migration.

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We observed a substantial numerical decrease in PCNA with siRNA against Ref-1 indicating a trend toward a decrease although this change did not reach statistical significance ( Fig. 3 E ).

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