Genetic variation in <i>PLEKHG1</i> is associated with white matter hyperintensities (n = 11,226).

The PLEKHG1 GWAS association we identified was validated in an independent population, although this did not quite reach statistical significance independently.

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There were nominally significant associations with expression of PLEKHG1 in brain and vascular tissues (further data available from Open Science Framework [table e-4]; osf.io/pkruv ), but none reached Bonferroni-corrected significance.

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