New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Of note, a signal near SLC26A9 , a known cystic fibrosis modifier gene 54 , was highly significantly associated with PEF in UK Biobank (P=3.97×10 −66 ) and nominally significant in SpiroMeta (P=6.93×10 −3 ), with consistent direction of effect, but did not meet the Tier 2 criteria.

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