Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity.

Thus, although all HFD-fed groups showed an increased islet area/pancreas area ratio, only the mice with hepatic expression of IR isoforms showed a trend towards reduced systemic insulin levels and a recovery of the first phase of insulin secretion, demonstrating that AAV-mediated specific hepatic expression of IR isoforms regulates the compensatory mechanisms of insulin resistance.

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