An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids.

whole exome sequencing rare variant HDL LDL triglyceride cholesterol genetics epidemiology Replication Results In the pooled HyperGEN and GENOA samples, POT1 , ITGA7 , and SLCO2A1 approached significant associations ( P = 0.020, P = 0.036 and 0.082, respectively) in the gene-based test ( Supplementary Table 1 ).

also in 127 other papers

In our study, rare variant rs11171663 in ITGA7 was significantly associated with TG in Caucasian samples from GOLDN, but the direction of effect was opposite in African American samples from HyperGEN and GENOA, yet the variant still approached significance ( P = 0.053).

also in 8,237 other papers