State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice.

The fraction of pairs firing synchronously in each animal tended to increase at intermediate stages of depletion, but did not reach statistical significance until end-stage ( Figure 2F ) (Ctl: 8.6 ± 7.8% n = 7 animals; G85%: 18 ± 14% n = 5 animals; G60%: 7.3 ± 7.3% n = 7 animals; G30%: 15 ± 11% n = 8 animals; G5%: 28 ± 23% n = 9 animals; Dunnett, Ctl vs. 5%, p = 0.04).

also in 111,027 other papers