ATL3 was significantly upregulated using both meta-analytical methods (adj P < .05), whereas ALOX15B (downregulated) was marginally significant in one case but showed a suggestive signal (adj P < .10) in the second method.
In addition, we tested whether the finding of a highly significant alteration in NPTX2 gene expression in the brain of SCZ patients ( Manchia et al., 2017 ) was consistently (downregulation) or discordantly (upregulation) replicated in peripheral tissues.
Pathway-Based Microarray Meta-Analysis The meta-pathway analysis conducted with MetaPath using the Molecular Signatures Database Hallmark gene set did not identify biological processes significantly perturbed after FDR correction, but 3 nominally significant processes ( supplementary Table 6 ).