Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies.

Front Neurosci · 2019 · PMC6403191 · PMID 30872998

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showed a trendno p-value reported

PICALM -AG and CLU -CC showed a trend for improvement in memory which only reached significance when APOE E3 was present ( Barral et al., 2012 ), highlighting that different genotype combinations at three AD genes produce different effects on a measurable phenotype that is AD-relevant.

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