ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.

Nat Commun · 2019 · PMC6403256 · PMID 30842415

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1a , although ABHD5 proficiency only showed a trend toward a positive correlation with IC50 in response to FU in MSI (dMMR) CRC cells, in MSS (pMMR) CRC cells, ABHD5 proficiency exhibited a significant positive correlation with the IC50 to FU.

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